Many of the non-hormonal methods of contraception currently being studied involve the vas deferens. The vas deferens is the tube that sperm pass through on their way to the penis. This tube is cut during a vasectomy. One promising avenue of research is a technique called reversible inhibition of sperm under guidance RISUG.
During this technique, a non-toxic synthetic chemical is injected into the vas deferens. The chemical reacts and blocks the vas deferens. It also kills sperm when they come into contact with it. The chemical is effective almost immediately after it is injected. The chemical stays in place until a man decides that he wants to have children.
It can then be washed out using another injection which dissolves and flushes it out of the vas deferens. A variation of this technique is the intra-vas device IVD. It involves injecting a "plug" into the vas deferens which can be removed later. The IVD filters out the sperm as it passes through the vas deferens. Reasearch published in found that blocking certain proteins in the bodies of male mice rendered them infertile, but did not affect their sexual behaviour or the quality of their sperm.
It prevented the sperm cells from being launched during ejaculation. When the mice's sperm was used to artificially inseminate female mice, it resulted in pregnancies and healthy baby mice. If a way can be found to block these proteins in human males, this may take research a step closer to producing a male contraceptive pill. However, the research is in the very early stages and a male pill has not been developed.
You can find out more about the research into proteins, mice and sperm. Other research is focusing on the epididymis. The Jiftip company says its product makes sex pleasurable again for men. We break down some of the basics surrounding what masculinity is, how it harms men, and what we can do about it. Ruined orgasms are about control, domination, and power. And with the right partner s , these aspects of kink can all be super sexy.
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But bigger, longer trials were needed to check it would work well enough as a birth control. And this is not the only prototype hormone-based male contraceptive Prof Wang has been testing. She and colleagues have come up with a body gel men in the UK will be trying as part of an international trial.
Users apply it daily to their back and shoulders, where it can be absorbed through the skin. Progestin hormone in the gel blocks natural testosterone production in the testicles, reducing sperm production to low or nonexistent levels, while replacement testosterone in the gel maintains sex drive and other functions that rely on the hormone.
And trials in men have suggested this is safe enough to move into the next phase of testing. Other scientists have been trying delivering longer-acting birth control hormones in a jab given every other month.
But they stopped enrolling men to their phase-two study , looking at the safety and effectiveness of the injection, after some of the volunteers reported side-effects, including mood disorders or depression. For men who don't fancy taking hormones, researchers have been looking at ways to block sperm flow, stopping it from ever leaving the penis - effectively, a non-surgical vasectomy.
Vasalgel - a polymer material that is injected into the two ducts that transports sperm from the left and right testicles to the penis - is being developed as a non-hormonal, reversible, long-acting male contraceptive.
So far, it has been tested in animals only - but the researchers behind it have recently received funding to look to begin human trials. Prof Richard Anderson, of the University of Edinburgh, is leading one of the UK trials that will test a contraceptive body gel on men.
He said the pharmaceutical industry had been slow to get behind the idea of a new male contraceptive despite good evidence that both men and their female partners would welcome the additional choice. With little industry involvement, he said, researchers had had to rely on charitable and academic funding, which took time. Allan Pacey, professor of andrology, at the University of Sheffield, said: "The development of a male birth control pill, or injection, has had a chequered history without much success so far and so it is good to see that new preparations are being tested.
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